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Symptoms may include: In cases of high creatinine due to medication toxicity: If a kidney infection (pyelonephritis) develops and treatment is neglected, the following symptoms may occur: In cases of glomerulonephritis, the symptoms associated with high creatinine may include: In cases of kidney failure, symptoms may include: Similar symptoms may also arise in conditions that can lead to kidney function impairment, such as high blood pressure, urinary tract obstruction, and heart disease

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While mild tiredness may be manageable with lifestyle adjustments, certain presentations of fatigue warrant prompt medical evaluation