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Six months of voluntary wheel running significantly downregulated the expression of Ferritin, HO-1, janus kinase 1 (JAK1), signal transducer and activator of transcription 3 (STAT3), DMT1, TFR, and hepcidin in the cerebral cortex of five familial Alzheimers disease (5FAD) mice, reduced A and IL-6 levels, inhibited A plaque deposition and neuroinflammation, thereby improving neurological deficits in AD mice ( 2 max significantly downregulated the levels of TFR1, TF, DMT1, FTL, FTH, mitochondrial Ferritin, -secretase, and APP in the cortical motor regions of aged amyloid precursor protein-C105 (APP-C105) mice, upregulated the expression of FPN1, Furin, and -secretase, significantly reduced Fe 2+ , Fe 3+ , and total iron content, inhibited brain iron accumulation and A plaque growth, thereby improving learning ability, memory, and cognitive function in aged APP-C105 mice ( G93A transgenic mice, significantly reduced the expression of FTL, FTH, Ferritin, TFR1, and APP, upregulated FPN1 expression, inhibited A and iron accumulation in skeletal muscle, and improved neural function in the mice
Show Notes Why the current protein RDA is too low, and why maintaining sufficient amino acid intake is vital for muscle preservation and health [A: 3:30, V: 0:11] Protein is an important topic Rhonda and Peter have probably talked to all the worlds experts on protein [Explore more at PeterAttiaMD and FoundMyFitness] They were chatting a moment about about the recommended daily allowance (RDA) for protein, and really what it should be called is the minimum daily allowance Recommended almost sounds like optimal The RDA is 0 Would you like access to extensive show notes and references for this podcast (and more)
doi:10.1016/j.jaac.2016.06.015CrossRefGoogle ScholarPubMed Arnold, LE, Ober, N, Aman, MG, et al
