In people who develop hyperglycemia on statinsor who begin with pre-diabetesconsider therapies that enhance GLP-1 signaling (GLP-1 receptor agonists, DPP-4 inhibitors) or improve insulin sensitivity (metformin) while continuing evidence-based lipid lowering
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Individuals with insulin resistance, type 2 diabetes, or previous weight loss plateaus may also benefit
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Semaglutide may slightly lower TSH in some people
The added glucagon activity appears to boost metabolic rate and fat burning, which likely explains the greater weight loss seen in trials
