A Phase 2 Dose Ranging, Randomized, Double Blind, Placebo-Controlled Study Evaluating the Safety, Tolerability, Pharmacokinetics and Efficacy of EDP-305 in Subjects With Primary Biliary Cholangitis (PBC) With or Without an Inadequate Response to Ursodeoxycholic Acid (UDCA) (2021)
An externally administered peptide must first survive formulation, administration, enzymatic degradation, distribution and clearance before reaching a tissue
Even if the backwashing is executed perfectly, improper handling during the subsequent settling phase can result in poor stratification, leaving behind a latent risk of cross-contamination
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Clin Nut 26(1):4150
There is no standardized product to study, which is part of why the evidence base is so thin