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In the research community, sustained or supraphysiologic IGF-1 exposure is associated with progressive abdominal distension (sometimes called 'GH gut') and concern for cardiac hypertrophy

The IGF-1 LR3 research community uses the same rule set, with the additional precaution of avoiding pre-bed dosing because of overnight hypoglycemia risk

In-depth Understanding of Age-Related Benefits of CJC-1295 and Ipamorelin Introduction to Age-Related Hormonal Changes As individuals age, the body undergoes various hormonal changes, notably a decline in growth hormone (GH) production

Ipamorelin Selectivity Studies Raun et al

Delving deeper, it was suggested that Ipamorelin might interface with, and perhaps elevate, IGF-I concentrations

These effects are believed to be related to the broader systemic benefits of optimized GH circulation on brain function and hormonal balance