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There are similar studies showing that arhalofenate acid activates AMPK in macrophages in vitro , inhibits the activation of NLRP3 inflammasomes, and reduces MSU-induced IL-1 production (Kim et al., 2016

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Synchronized L1 progeny from either F1 or F2 generations were dispensed onto 96-well plates containing 40 M lethal dose of avocadene acetate in OP50 resuspended in S-complete

But the dual receptor activation means the gastrointestinal effects can be more intense, particularly during dose escalation