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When autophagy initiates, LC3-I undergoes a critical modification involving conjugation to phosphatidylethanolamine (PE), converting it to LC3-II, which then localizes to the lipid membrane of nascent autophagosomes (Lazova et al., 2012)

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Key interactions, such as reduced cyclosporin absorption leading to Evan's syndrome relapse, and enhanced effects of warfarin's anticoagulation due to decreased vitamin absorption, underline the importance of vigilant monitoring and potentially supplementing vitamins in individuals taking orlistat [39, 42]

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