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ER/ER ratio and aromatase expression levels as well as 2-hydroxyestrone:16-hydroxyestrone ratios are becoming used as biomarkers to direct phytoestrogen or DIM (diindolylmethane) supplementation, whereas the NF-B, STAT3 and PI3K/Akt phosphorylation status potentially indicating curcumin, resveratrol or polyphenols use for chemosensitizing

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January 2025