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The primary pathway involves its rapid reaction with superoxide radicals (O 2 ) to form peroxynitrite (ONOO), a highly potent and damaging oxidant

Titration: There is generally no need for upward titration with B-complex vitamins as one might do with certain drugs, but if a patient is frail or known to react to injections, the provider may choose to start at a lower dose (for example 0.25-0.5 mL) and then increase to 1 mL as tolerated

Metal ion coordination and gene regulation Copper-peptide complexes: GHK-Cu contains copper(II) ion coordinated by glycine amino group, histidine imidazole, and lysine forming square planar complex

The search was performed for +2 to +4 charge states at a MS tolerance of 0.05 u on precursor ions and 0.1 u on fragment ions

2018 Aug 25;547(12):395403

The peptide was first synthesized by researchers investigating cytoprotective proteins found in gastric juice