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Most of the earliest incretin-targeting agents to be approved fell into the class of DPP-4 inhibitors

In the future, the companies that make breakthroughs in long-acting formulations, multi-target drugs, and oral drug development will be well-positioned to lead the GLP-1 market.

de Souza HS, Fiocchi C

Stopping the medication to avoid temporary fatigue often trades a short-term problem for a long-term one

Raushel FM, Cleland WW

"These groundbreaking medications are poised to revolutionize cardiovascular care and could dramatically enhance cardiovascular health." In two new substudies of the SELECT Trial, which included people who had overweight or obesity according to their BMI and had established cardiovascular disease but not diabetes, researchers looked at whether once weekly semaglutide (2.4 mg) reduced rates of all-cause death, cardiovascular death and noncardiovascular death, including death from COVID-19, and whether sex impacts the efficacy and safety of the drug