started smoking cigarettes When did humans start smoking, anyway? Smoking - Health Risks, Addiction,

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van der-Toorn M, Rezayat D, Kauffman HF, Bakker SJL, Gans ROB, Koe GH, et al: Lipid-soluble components in cigarette smoke induce mitochondrial production of reactive oxygen species in lung epithelial cells

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A few drugs are enormously dangerous in the short-term but not the long-term (heroin), or vice versa (tobacco)