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J Cell Physiol 233:49354948 Dornan GL, Burke JE (2018) Molecular mechanisms of human disease mediated by oncogenic and primary immunodeficiency mutations in class IA phosphoinositide 3-kinases

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Premature hair greying: It is a significant impact of smoking that is visible in smokers aged 25 to 30

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Smoking also disrupts apoptosis and autophagy