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Their co-consumption is not accidental they have specific, documented pharmacological interactions that make each more pleasurable when used together

King AC, Smith LJ, McNamara PJ, Cao D (2018) Second generation electronic nicotine delivery system vape pen exposure generalizes as a smoking cue

Cigarettes separated with some shredded tobacco scattered, with coins in pennies around and some dollars, isolated on white background

Several studies reported that urinary 8-OHdG levels [26,27,28] and salivary 8-hydroxyguanine levels [29, 30] correlated with smoking

In animal models, mice were exposed for 60 weeks to the e-cigarette with a concentration of nicotine from 0 to 24 mg/mL showed endothelial dysfunction and an increase in endothelial ROS, in addition to a thickening of the vessel wall were dependent on nicotine concentration (186)

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