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Randomized, Double-Blinded, Placebo-Controlled Trials Clinical trials that are randomized, double-blinded, and placebo-controlled are the gold standard for testing the effectiveness of new treatments

Immediate discontinuation is required for confirmed allergic reactions

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doi: 10.1111/dom.14232 26 ArodaVRBainSCCariouBPiletiMRoseLAxelsenMet al

The recent surge in demand for Ozempic and Wegovy, driven largely by their perceived potential for weight loss touted on social media, has contributed to the semaglutide shortage

Tirzepatide shows slightly greater average weight loss in clinical trials (15-22% vs 15% body weight), but individual response varies