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Epidemiologic research shows that people who use both alcohol and tobacco have much greater risks of developing cancers of the oral cavity (mouth), pharynx (throat), larynx, and esophagus than people who use either alcohol or tobacco alone

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the 2013 review suggests that the lower limit causing fatal outcomes is 5001000 mg of ingested nicotine, corresponding to 6.513 mg/kg orally

THC activates the receptors that lead to signaling involved in physiological responses like lower blood pressure, euphoria, and so on

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