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Biological repair and adaptation rarely depend on a single signaling molecule, and many modern studies increasingly focus on network-level interactions rather than isolated mechanisms

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The pathophysiology of DDES is complex, involving lacrimal gland mitochondrial dysfunction, neuro-inflammation, ocular surface dysbiosis, and meibomian gland dropout [122,123,124]

& Segal, K

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Impurity profiling using high-resolution LC-MS/HRMS and HPLC detects any process- or degradation-related impurities, ensuring equivalence to the RLD