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Basal insulin plus GLP-1RA resulted in less hypoglycemia and weight loss compared to other insulin regimens [3334]

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In contrast, adult-onset deletion of the Keap1 gene exclusively in renal tubular cells caused no abnormalities in renal structure or function [67], demonstrating that overactivation of Nrf2 in the mature renal epithelium makes kidneys resistant to oxidative injuries without any significant abnormalities

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