Proper thyroid hormone replacement or stabilization is therefore the foundation of any weight management plan for people with thyroid disease, and additional therapies must be layered carefully on top of established thyroid treatment
However, this is a gray area legally and medically
Costanzo M, VanderSluis B, Koch EN, Baryshnikova A, Pons C, Tan G, et al
A total of 149 incident fractures were reported, including 55 vertebral, 27 hip, 28 rib, six wrist and 16 upper and 17 lower extremity fractures. After adjustment for sex hormone binding globulin (a blood protein), serum testosterone and serum estradiol levels were associated with overall fracture risk, according to the authors
Tirzepatide has less real-world exposure time but has shown no concerning signals through extended clinical trial follow-up periods
In contrast, the effect on cardiovascular death did not reach at the statistical significance (HR 0.82, 95% CI 0.571.16), possibly due to lower event rate