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This finding is in agreement with other studies that showed low serum uric acid in regular smokers1,50 and reduction of antioxidants including uric acid in smokers51,52 indicating that oxidative stress increases everytime a cigarette is smoked.1 Other studies proved that even nonsmokers exposed to cigarette smoke have a significantly lower plasma antioxidant status than unexposed nonsmokers do, independent of differences in dietary antioxidant intakes.51 It even proved that administration of uric acid raises circulating antioxidant defenses and allows restoration of endothelium-dependent vasodilation.11,52 Therefore, high serum uric acid concentrations might be protective in situations characterized by increased cardiovascular risk and oxidative stress as smoking,11 and by reducing its level it increases susceptibility to oxidative damage and accounts for the excessive free radical production.53 Therefore, the possibility that uric acid confers protection against the development of atherosclerosis, in view of its antioxidant properties, has been recognized.54,55 In this study, serum creatinine, FEuric acid and Uuric acid/Ucreatinine ratio are not significantly differ between two groups, in addition to that FEuric acid and Uuric acid/Ucreatinine ratio values lie within the mean SD observed in the control group by other studies.19,56-58 Since these tests have been reported to be useful to evaluate renal handling of uric acid59-63 and as serum uric acid concentrations are highly dependent on endogenous production as well as renal excretion.64,65 Therefore, low serum uric acid level in smokers is attributed to reduction of endogenous production

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