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According to recent reports, ALS is associated with increased apurinic/apyrimidinic DNA sites and activation of DNA damage response (DDR)

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5-Amino-1-methylquinolinium (5-Amino-1MQ) is a selective small molecule inhibitor of the enzyme nicotinamide N-methyltransferase (NNMT), a cytosolic enzyme that plays a critical role in cellular metabolism and energy homeostasis

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