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Genotoxicity As a direct consequence of a reduction in carcinogenic toxicant emission, cMRTP aerosols should display significantly reduced mutagenicity and genotoxicity in standard cell-based assays, such as the Ames, in vitro micronucleus and the mouse lymphoma assays [32, 50]

Generally, it is accompanied by the following symptoms: A loss of feeling in the tongue, fingers, and toes Dizziness Muscle twitches and cramps Seizures It is most often brought on by low magnesium levels, low levels of vitamin D, untreated kidney disease, a complication of thyroid surgery, cancer treatment medications, or pancreatitis (inflammation of the pancreas)

Available at: ahrq.gov/professionals/ cliniciansproviders/guidelines-recommendations/tobacco/5steps.html

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Bibcode:2020ESPol.112..453F

Nicotine is the common substance in cigarette smoke and snuff