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For researchers weighing over 300 pounds (136 kg), the standard 4-week escalation is typically well tolerated, and the 12mg maintenance dose is strongly recommended

However, as with any supplements, these should only be taken in safe doses after consulting with a medical professional

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Weight gain is a common side effect of surgery which could result from certain medications, lack of movement or exercise, and fluid retention, among other reasons

doi: 10.1016/j.jns.2016.10.052 41 DengW.SaxeM