If you are lightening your skin while tanning in the sun, you are fighting a losing battle
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17-hydroxylase (CYP17A1), the rate-limiting enzyme in androgen biosynthesis, is modulated by PKA and MAPK-dependent phosphorylation
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The first-line defense mechanism is the most efficient and involves antioxidant enzymes such as superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx)
The reduced enzymatic activity increases cellular concentrations of both substrates that NNMT would otherwise consume: S-adenosyl-L-methionine (the universal cellular methyl donor) and nicotinamide (the NAD + salvage precursor)