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However, long-term studies specifically tracking extended use are lacking

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Various alternatives to the embodiments described herein are optionally employed

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265 Additionally, activation of the Wnt/-catenin signaling pathway has been shown to inhibit IL-1-induced apoptosis of intestinal epithelial cells, increase the expression of ZO-1 and Occludin, improve the structure and function of the intestinal barrier, and reduce inflammatory cell infiltration