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Another common polymorphism is A1298C, in which adenine is replaced by cytosine resulting a conversion of glutamate to alanine at 429 residue, which also diminishes the enzyme activity

The formation of 5-methylTHF depends on N 5,10 -methylenetetrahydrofolate reductase (MTHFR), which catalyzes the reduction of N 5,10 -methylenetetrahydrofolate (5, 10-methyleneTHF) (Fig

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