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10.1523/JNEUROSCI.1423-10.2010 [DOI] [PMC free article] [PubMed] [Google Scholar] Everson CA, Laatsch CD, Hogg N (2005) Antioxidant defense responses to sleep loss and sleep recovery

Whilst oral bioavailability is relatively poor (less than 5% reaches systemic circulation due to extensive first-pass metabolism), sufficient absorption occurs to produce measurable pharmacological effects in research settings

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