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Nature 392 , 565568 (1998)

Higher adipose tissue mass means more receptor targets for AOD-9604, more fat to mobilize, and more absolute fat loss possible

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However, under mitochondrial stress, HRI activation occurs through a distinct mechanism, which centers on the mitochondrial signal relay protein DELE1

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doi: 10.1089/ars.2013.5255, 6 CravenA