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Elizabeth Ko and Eve Glazier stated that drinking soda was linked to many adverse health conditions, including "obesity, poor blood sugar control and diabetes

doi: 10.3390/jpm12030458 67 DoanH

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Upon recognition, unfolding and transfer of the de-ubiquitinated target protein by the 19S regulatory cap into the interior of the cylindrical 20S proteasome core particle, protein degradation is facilitated by catalytic -subunits having nucleophilic N-terminal threonine (Thr1) residues

What matters is the approach: both start low and titrate up over months